2017 Fiscal Year Final Research Report
Assessment of the relationship between pouchitis and internal antimicrobial protein after surgery in ulcerative colitis
| Project/Area Number |
15K19868
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
KOUNO EMIKO
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 潰瘍性大腸炎 / 家族性大腸腺腫症 / 回腸嚢炎 / 抗菌タンパク |
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| Outline of Final Research Achievements |
Total colectomy with ileal pouch-anal anastomosis (IPAA) is a standard surgical procedure for ulcerative colitis (UC) and familial adenomatous polyposis (FAP). Pouchitis is a major complication after IPAA in patient with UC, which pathogenesis is unknown. RELMβ/FIZZ2 (resistin-like molecule beta／Found in inflammatory zone-2) is a colonic epithelial protein which expression decreases in patients with UC in our past study. This study aims to evaluate (1) the antimicrobial activity of RELMβ/FIZZ2, (2) the factors which modulate RELMβ/FIZZ2 expression, and (3) the expression of RNA and/or antimicrobial protein in ileal pouch and stool after IPAA.
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| Free Research Field |
外科
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