Mechanism and Relationship for medical treatment of DAXX gene in pancreatic neuroendocrine tumor

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19869
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: Aoki Takeshi 東北大学, 大学病院, 助教 (10636955)
• Research Collaborator: SAKATA NAOAKI 東北大学, 大学病院, 助教 (50431565)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: pNET / DAXX / プロゲステロン受容体 / インスリン

Outline of Final Research Achievements

At first, I focused on the Progesterone receptor (PgR) which was suggested the relationship to prognosis of pancreatic neuroendocrine tumor (pNET). I studied the relationship between PgR and ability of insulin production in pNET. PgR expression was associated with insulin expression in pNET. PgR showed high expression in the order of Insulinoma, insulin positive non-functional pNET (ins (+) NF) and insulin negative non-functional pNET (inf (-) NF). Insulinoma and ins (+) NF shared common clinical characteristics, morphology and PgR expression status. On the other hand, ins (-) NF might have a unique pathogensis with little association with PgR expression.

Free Research Field

膵神経内分泌腫瘍