Exploratory research for chemoresistance related microRNA expression in patients with esophageal squamous cell cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19878
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Nagoya University
• Principal Investigator: NIWA Yukiko 名古屋大学, 医学部附属病院, 病院講師 (50746401)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: マイクロRNA / エクソソーム / 食道癌L1 / テーラーメード治療 / NACRT

Outline of Final Research Achievements

Six pretherapeutic plasma samples of each three different chemotherapy-sensitive and chemotherapy-resistant ESCC patients were selected for the 3D-GENE microarray analysis . Twenty-eight miRNAs have been reported to be upregulated in plasma of chemotherapy-resistant ESCC patients. We chose miR-193b- 5p, miR-873-3p and miR-23a-5p of them as candidates for therapeutic effect predictive markers in this study.
The levels of miR-193b- 5p, miR-873-3p and miR-23a-5p were examined for 111 plasma samples in ESCC patients who received neoadjuvant chemotherapy with cisplatin/5-FU. MiR-193b-5p and miR-873-3p were significantly highly expressed in plasma of chemotherapy-resistant ESCC patients than those of chemotherapy-sensitive patients (P = 0.044, P = 0.025). Hence, patients with high expression of miR-193b-5p or miR-873-3p in plasma will become to resistant chemotherapy with cisplatin/5-FU as the first line of ESCC in Japan.

Free Research Field

消化器外科学