2016 Fiscal Year Final Research Report
Analysis of innate immune cells which induces development of pathogenicTh17 cells in human intestinal lamina propria
| Project/Area Number |
15K19885
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ヒト腸管粘膜固有層 / MDR1陽性Pathogenic Th17細胞 / 自然免疫担当細胞 / 炎症性腸疾患 |
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| Outline of Final Research Achievements |
We identified 4 lamina propria cell subsets (CD14-CD11clow, CD14-CD11chigh, CD14+CD163low, CD14+CD163high) in the human colon. Allogenic CD4+ MDR1- effector T cells were co-cultured with these cells, and the frequency of MDR1+ pathogenicTh17 cells were analyzed by Rh123 assay. The frequency of MDR1+ pathogenicTh17 cells in Crohn’s disease was similar to that in the normal colon. We could not found the innate immune cell which induced development of pathogenicTh17 cells.
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| Free Research Field |
医歯薬学
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