2017 Fiscal Year Final Research Report
IMiDs enhanced the anti-tumor of chemotherapeutic agent on pancreatic cancer
| Project/Area Number |
15K19911
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
SAITO Nobuhiro
SHIRAI Yoshihiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | IMiDs / 膵臓癌 / NF-κB / gemcitabine / nab-paclitaxel / アポトーシス / 細胞周期停止 / 血管新生抑制 |
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| Outline of Final Research Achievements |
Anticancer drug-induced nuclear factor-kappa B (NF-κB) attenuates chemosensitivity. Gemcitabine and nab-paclitaxel is recommended for unresectable pancreatic cancer, however, the median survival time is only 8.5 months. Thalidomide suppresses NF-κB activation in digestive cancer, therefore, we hypothesized that pomalidomide, a third generation of IMiDs, also improve chemoresistance on pancreatic cancer cells.
For both in vitro and in vivo, pomalidomide enhanced the antitumor effects of gemcitabine/nab-paclitaxel and gemcitabine/S-1. Especially, to the best of our knowledge, current study firstly demonstrated that pomalidomide enhanced p53 on pancreatic cancer cells. Pomalidomide also induced apoptosis, cell cycle arrest, and anti-angiogenesis on pancreatic cancer. This new regimen would be a new therapeutic approach.
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| Free Research Field |
消化器外科学
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