2017 Fiscal Year Final Research Report
Development of novel nucleic acid therapy for brain tumor stem cells using inactivated viral particle
| Project/Area Number |
15K19948
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
SUGII NARUSHI 筑波大学, 人間総合科学研究科・疾患制御医学専攻
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 不活化ウイルス粒子 / microRNA / 脳腫瘍幹細胞 / 核酸医薬療法 |
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| Outline of Final Research Achievements |
Hemagglutinating virus of Japan envelope (HVJ-E) derived from inactivated replication-defective Sendai virus was originally developed as a versatile drug delivery system. We have shown the ability of HVJ-E to highly introduce oligonucleotide as a therapeutic molecule into glioma stem-like cells. In the present study, we have shown that introduction of stemness inhibitory microRNAs such as miR-218 or miR-34a using HVJ-E vector may become a novel nucleic acid therapy for malignant gliomas.
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| Free Research Field |
脳神経外科学
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