Complete regulation of glioma stem cell by notch and Akt signal inhibition

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19956
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: tanaka shingo 金沢大学, 医学系, 協力研究員 (40507084)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: Notch阻害薬 / Akt阻害薬 / 膠芽腫

Outline of Final Research Achievements

Glioblastoma is the most malignant primary brain tumor in humans. The patinets with glioblastoma have a uniformly poor prognosis. The significance of targeting glioblastoma-stem cells may be important for successful treatment. In this study, we analyzed the efficacy of the Nothc inhibitor and Akt inhibitor for glioblastoma stem cell with Notch inhibitor resistance. Notch inhibitor concomitant Akt inhibitor treatment enhanced the effect by monothearapy such as suppression of cell proliferation and stemness maintenance, and promotion of apoptosis.

Free Research Field

脳神経外科学