2016 Fiscal Year Final Research Report
Mutational landscape and clonal architecture in secondary glioblastomas
| Project/Area Number |
15K19964
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | グリオーマ / クローン進化 / 腫瘍内多様性 |
|---|
| Outline of Final Research Achievements |
Lower grade glioma (WHO grade II and III glioma) is slowly progressive but incurable disease. Recently, our group revealed that lower grade glioma is divided into three subgroups based on genetic alterations. In this study, we identified subgroup-specific genetic alterations that affected the tumor progression in lower grade glioma. The subset of patients with identified genetic alterations had poor survival, which will lead us to the better management of LGG patients.
|
| Free Research Field |
脳腫瘍学
|
