The involvement of reelin in the cortex-dpendent skilled learning after a stroke

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19966
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Osaka University
• Principal Investigator: Nishibe Mariko 大阪大学, 医学系研究科, 招へい教員 (50638757)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: Motor Learning / Reelin

Outline of Final Research Achievements

The physiological functions of reelin in vivo during adulthood remain controversial. We tested if there is a behavioral phenotype in the adult heterozygous reeler mice on the skilled reach task. The heterozygous reeler mice could learn to reach and grasp singly presented pellets, but the successfully retrieved number of pellets was lower than that achieved by the WT. We then assessed the physiological integrity of the motor cortex in HRM and WT littermates, before and after the training on skilled reach, using intracortical microstimulation. We found that this forelimb training exerted bilateral effects on the cortical forelimb map constitution. The level of synaptophysin and neurofilament expression levels heighten in the WT post-training. We are currently summarizing the results for post-stroke learning outcome measures.

Free Research Field

神経科学