2017 Fiscal Year Final Research Report
Telomere maintenance in meningiomas
| Project/Area Number |
15K19968
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
Eino Daisuke 大阪大学, 医学部附属病院, 医員 (70726520)
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| Research Collaborator |
HASHIMOTO Naoya
FUJIMOTO Yasunori
ARITA Hideyuki
HIRAYAMA Ryuichi
ACHIHA Takamune
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 髄膜腫 / テロメア |
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| Outline of Final Research Achievements |
Telomere maintenance is mandatory for cancer proliferation. In this research, we investigated the mechanisms of telomere lengthening or maintenance in meningiomas. Upregulating mutations in the promoter of telomerase reverse transcriptase were infrequent in meningiomas, and were invariably observed in aggressive malignant meningiomas. We also analyzed the activity of telomerase in meningioma samples, but telomerase reactivation was not observed in most tumors. Thus, telomerase is rarely reactivated in meningiomas, and this type of brain tumor might depend on other mechanisms of telomere lengthening.
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| Free Research Field |
脳神経外科学
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