MicroRNA regulating metabolic stress enhances therapeutic sensitivity in glioma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19973
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kagawa University
• Principal Investigator: Ogawa Daisuke 香川大学, 医学部附属病院, 病院助教 (70524057)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: microRNA / miR-451 / 脳腫瘍 / グリオーマ / AMPK / Oct1

Outline of Final Research Achievements

The aim of this study was to see if miR-451, a one of　microRNAs which regulates　metabolic　stress, will increase therapeutic sensitivity of brain　tumor　cells. Upregulation of miR-451 in brain tumor cells increased chemo-sensitvity and radiation sensitivity causing brain tumor cells to death. We found Oct1 as a positive transcription factor to increase expression level of miR-451. We also found that miR-451 expression level was increased in high blood glucose model rats.

Free Research Field

脳腫瘍