2016 Fiscal Year Final Research Report
The study of molecular target therapy for brain tumor stem cells
| Project/Area Number |
15K19979
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
Kikuchi Ryogo 慶應義塾大学, 医学部(信濃町), 助教 (10594723)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 脳腫瘍幹細胞 / 悪性神経膠腫 / MIF / DEPDC1 |
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| Outline of Final Research Achievements |
We analyzed the function of MIF and novel oncoantigen, DEPDC1, in malignant glioma. MIF bound directly to p53 and inhibited its function in brain tumor stem cells and glioma cells. MIF knockdown inhibited tumor progression in mouse brain tumor model. DEPDC1 promoted cell proliferation through NF-κB signaling pathway in glioma cells. DEPDC1 knockdown prolonged overall survival in mouse model using induced brain tumor stem cells.
Our data suggested that MIF and DEPDC1 were useful target molecules for the treatment of glioma.
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| Free Research Field |
脳腫瘍
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