Application of a novel boronated porphyrin as a dual sensitizer for both PDT and BNCT

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19982
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Osaka Medical College
• Principal Investigator: Hiramatsu Ryo 大阪医科大学, 医学部, 助教 (40609707)
• Research Collaborator: M. Graça H. Vicente Louisiana State University, Department of Chemistry
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 悪性神経膠腫 / BNCT / PDT / ホウ素化ポルフィリン / CED / ホウ素化クロリン

Outline of Final Research Achievements

In this study, H2OCP as a novel boronated porphyrin has been proven to be a promising photosensitizer for PDT. H2OCP has also been proposed as a potentially effective replacement of BPA or BSH, or as a replacement of both BPA/BSH. This study provides more evidence that H2OCP could be an effective novel dual sensitizing agent for use in both PDT and BNCT. And Boronated chlorin as well as a boronated porphyrin is a large-ring compound and has a tumor affinity. So, boronated chlorin has also been proven to be a dual sensitizing agent for use in both PDT and BNCT. In this study, we also searched a useful drug for a dual sensitizing agent.

Free Research Field

悪性脳腫瘍