Establishment of clinically applicable conditions for prevention of steroid induced osteonecrosis using quantitative evaluation by higher-resolution MRI

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20010
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Ishida Masashi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40725660)
• Research Collaborator: IKOMA Kazuya 京都府立医科大学, 医学(系)研究科(研究員), 講師 (50516044)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 特発性大腿骨頭壊死症 / MRI / 電気刺激

Outline of Final Research Achievements

This study aimed to evaluate femoral perfusion using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a steroid-induced osteonecrosis (ON) model. Seven rabbits underwent electrical stimulation (ES) (ES group), and seven rabbits did not (control group). DCE-MRI was performed before steroid and 1, 5, 10, and 14 days after steroid. The enhancement ratio, initial slope, and area under the curve were analyzed.These parameters were evaluated after steroid administration in each group and between the two groups, and the ratios of ON in both groups were compared. In the control group, the minimum values of all parameters decreased significantly after steroid administration (P < 0.05), but in theES group, the parameters did not decrease. In the control group, ON was detected in three of five rabbits. In the ES group, ON was not detected. These results suggest that increased femoral blood flow elicited by ES may be related to ON prevention after steroid administration.

Free Research Field

特発性大腿骨頭壊死症