2016 Fiscal Year Final Research Report
The Pathomechanism of Pain in Elderly Patients with Musculoskeletal Ambulation Disability Symptom Complex
| Project/Area Number |
15K20016
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 慢性疼痛 / 骨粗鬆症 / サルコペニア / 変形性関節症 |
|---|
| Outline of Final Research Achievements |
In the current study, we elucidated the patho-mechanism of low back pain and joint pain in elderly patients or animal models with osteoporosis or sarcopenia or osteoarthritis. Several molecules including inflammatory cytokines, various growth factors and pain-related molecules were observed in osteoporotic bone marrow, high aged muscle tissue and synovial tissue in osteoarthritis joints. In addition, multiple nerve fibers with pain-related molecules in osteoporotic vertebral body were observed. These findings might be related with pain in elderly patients.
|
| Free Research Field |
脊椎外科
|
