A proteomic analysis to identify novel proteins related to mechanisms of tumor cell invasion in myxofibrosarcoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: Kikuta Kazutaka 慶應義塾大学, 医学部(信濃町), 助教 (30383798)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: Myxofibrosarcoma / Invasion / Proteomics / DCBLD2 / 2D-DIGE

Outline of Final Research Achievements

Myxofibrosarcoma (MFS) is a mesenchymal malignancy characterized by frequent recurrence even after radical wide resection. To optimize therapy for MFS patients, we aimed to identify candidate tissue biomarkers of MFS invasion potential. We performed protein profiling in invasive and non-invasive MFS and detected a number of differentially expressed proteins. Among them, DCBLD2 was identified as a novel factor associated with tumor cell invasion in MFS, suggesting its potential clinical application as a biomarker for MFS prognosis. This is the first report about possible clinical utility of DCBLD2 in sarcomas. Further investigation of the detected proteins may produce additional biomarkers or clinical targets in MFS.

Free Research Field

整形外科、骨軟部腫瘍、希少がん、プロテオミクス