2017 Fiscal Year Final Research Report
Regulation of osteophyte formation in knee osteoarthritis by modulating the function of perlecan expressed in synovium
| Project/Area Number |
15K20019
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
ISHIJIMA Muneaki 順天堂大学, 医学(系)研究科(研究院), 准教授 (70365576)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 変形性膝関節症 / 滑膜 / 骨棘 / パールカン / 軟骨分化 |
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| Outline of Final Research Achievements |
As the pathology of knee osteoarthritis (knee OA) is diverse, we focused on synovitis and osteophyte formation in the knee OA. The aim of this study was to investigate the role of perlecan expressed in synovium in the early stage of synovitis and osteophyte formation in knee OA. The absence of synovial perlecan suppressed osteophyte formation and enhanced synovitis, although there was no difference in articular cartilage degeneration in the early stage of knee OA. These results suggest that that perlecan plays an important role for not only the cartilage differentiation from synovial mesenchymal cells but also for the synovial inflammation, which may be involved in osteophyte formation.
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| Free Research Field |
整形外科
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