Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20026
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Asahikawa Medical College
• Principal Investigator: KANDA Hirotsugu 旭川医科大学, 医学部, 講師 (00550641)
• Research Collaborator: IIDA Takafumi 旭川医科大学, 医学部, 助教 (40468442) ; KANDA Megumi 旭川医科大学, 医学部, 助教 (50516820) ; Hao Shuanglin University of Miami, Research Assoc, Professor
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 神経障害性疼痛 / ミトコンドリア / 遺伝子治療

Outline of Final Research Achievements

In summary, mitochondrial division is critical for the maintenance
of the structure and function of neurons. Although the mechanisms underlying HIV-related neuropathic pain are poorly understood, the current results provide important insights into the pathogenesis of mitochondrial division in the HIV-related neuropathic pain state.

Free Research Field

麻酔科・疼痛管理