2017 Fiscal Year Final Research Report
The effect of alpha7 acetylcholine receptor stimulation on muscle atrophy by inflammatory cytokines
| Project/Area Number |
15K20027
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Research Collaborator |
Martyn Jeendra ハーバード大学, 医学部, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アセチルコリン受容体 / 筋萎縮 / 炎症 |
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| Outline of Final Research Achievements |
Differentiation of myoblasts into myotubes in the presence of inflammatory cytokines was inhibited. In the absence of inflammatory cytokines, stimulation of α7 acetylcholine receptor by GTS21 increased myotube diameter and promoted expression of heavy chain myoglobin, but similar effects were not observed in the presence of inflammatory cytokines. In the presence of inflammatory cytokines it may be difficult to obtain a muscle hypertrophic effect by stimulation of GTS21. Previous published papers reported that muscle atrophy of mice was suppressed by administration of GTS 21 but the results of the present study are not due to direct action on muscle cells but the possibility that another mechanism of action may be involved.
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| Free Research Field |
麻酔
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