Control of neurotoxicity of inhaled anesthetics by endoplasmic reticulum chemical chaperone

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Chiba University
• Principal Investigator: KOMITA Mari 千葉大学, 医学部附属病院, 助教 (90589194)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 麻酔薬 / 神経細胞死 / ストレス

Outline of Final Research Achievements

· Purpose: In recent years, neurotoxicity due to anesthetic has been pointed out. We investigated the molecular mechanism of neurotoxicity by inhalation anesthetics using gene mutant mice with impaired endoplasmic reticulum function.
· Results: Exposure of mutant BiP (endoplasmic reticulum chaperone molecule) knock-in mice and wild type mice to the inhalation anesthetic sevoflurane during embryonic development tends to induce more neuronal cell death in mutant BiP knockin mice in the short term It was done. Suggesting the possibility that cognitive decline due to aging may be accelerated in the long term.
· Discussion: It is suggested that inhalation anesthetics inhibit endoplasmic reticulum function, which may lead to neurological disorders both short-term and long-term. In individuals sensitive to neurotoxicity, it is necessary to consider the amount of anesthetic to be used.

Free Research Field

麻酔科学