Modification of general anesthetic actions in diabetes model rats and clinical implications for anesthesia managements in diabetes patients

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20033
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: University of Toyama
• Principal Investigator: Honda Yasuko 富山大学, 附属病院, 助教 (50724572)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / GKラット / 海馬 / シナプス伝達 / 全身麻酔薬 / チオペンタール

Outline of Final Research Achievements

It has been reported that diabetes impairs hippocampal functions in the central nervous system. In order to demonstrate modification of general anesthetic actions in diabetes, we have studied effects of thiopental on hippocampal synaptic transmission in diabetes model rats (GK rats). The results indicated that diabetes attenuates the inhibitory neurotransmitter (GABA) due to the impairment of GABA recruitment at presynaptic terminals, suggesting that diabetes deteriorates postanesthetic cognitive dysfunction or emergence agitation in clinical anesthesia.

Free Research Field

麻酔科学