Hypoxia-Inducible Factor as a Therapeutic Target for Acute Respiratory Distress Syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20054
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: TOJO Kentaro 横浜市立大学, 医学部, 助教 (80737552)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ARDS / エネルギー代謝 / 低酸素誘導性因子 / 解糖系

Outline of Final Research Achievements

Bioenegertic failure due to mitochondrial dysfunction underlies the alveolar epithelial injury during acute respiratory distress syndrome (ARDS). In the present study, we demonstrated that inhibition of oxygen sensing prolyl hydroxylases (PHD) protects alveolar epithelial cells from bioenertic failure and cell death caused by experimental ARDS. The protective effects are mediated by HIF-1-dependent enhancement of glycolysis. These findings suggest that acitvation of HIF-1 might be a novel therapeutic approach for ARDS.

Free Research Field

集中治療医学