Identification of novel CRPC therapeutics by inhibition of activated functional RNA signaling

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Chiba University
• Principal Investigator: GOTO Yusuke 千葉大学, 医学部附属病院, 医員 (00710576)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 前立腺癌 / マイクロRNA / 去勢抵抗性前立腺癌

Outline of Final Research Achievements

Understanding the molecular mechanisms of the androgen-independent and metastatic signaling pathways underlying castration-resistant prostate cancer (CRPC) using current genomic approaches would help to improve therapies for and prevention of the disease. We sequenced small RNA libraries isolated from normal prostate tissue, prostate cancer (PCa) tissue and CRPC tissue. 267 miRNAs were significantly downregulated in CRPC compared with normal prostate specimen. miR-221/222 cluster was significantly downregulated in CRPC specimen. Gene expression data and in silico analysis demonstrated miR-221/222 regulated Ecm29 gene, which was highly expressed in CRPC specimen.

Free Research Field

医歯薬学