2016 Fiscal Year Final Research Report
The analysis of the differences in antibody reaction against ABO antigen between red blood cells and renal endothelium
| Project/Area Number |
15K20074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 腎移植 / ABO血液型抗原 / 抗体 |
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| Outline of Final Research Achievements |
Despite the presence of antigens on the graft's vascular endothelium and the presence of antibodies in recipients' blood, clinical rejection does not always occur in ABO incompatible kidney transplantation. This phenomenon is called as accommodation. However, the mechanisms are undefined.
We developed glycoconjugate microarray which is mimicked ABO blood group antigens expressed on human renal endothelium. In this study, we compared anti-A and anti-B antibodies reaction between red blood cells and renal endothelium. We found that antibodies production against donor blood group antigens of renal endothelium specifically inhibited after ABO incompatible kidney transplantation. This may be the mechanism of accommodation.
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| Free Research Field |
移植免疫学
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