Targeting therapy of hedgehog signaling in metastatic renal cell carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20090
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: FURUKAWA JUNYA 神戸大学, 医学部附属病院, 講師 (20448179)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 腎細胞癌 / 標的治療 / Hedgehog経路

Outline of Final Research Achievements

This study reports that retrospectively reviewed clinicopathological data from a total of 39 consecutive Japanese patients undergoing radical nephrectomy, who were diagnosed with metastatic clear cell renal cell carcinoma and subsequently treated with sunitinib as a first-line therapy, and evaluated whether expression levels of Hedgehog signaling-related proteins and major molecular targets of sunitinib in primary RCC specimens could be used as a reliable prognostic factor for this cohort of patients. We concluded that GLI2 appeared to be associated with the prognosis of Japanese patients who were treated with sunitinib as a first-line therapy for m-ccRCC. Furthermore, GLI2 is involved in the acquisition of resistance to sunitinib in RCC.

Free Research Field

泌尿器癌治療