2017 Fiscal Year Final Research Report
Role of Epac in bladder cancer
| Project/Area Number |
15K20095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Tokyo Medical and Dental University (2016-2017)
Kyushu University (2015) |
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Principal Investigator |
ITSUMI Momoe 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (40585890)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 膀胱癌 / 遊走能 |
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| Outline of Final Research Achievements |
We report that EPAC1 and EPAC2 expression levels were significantly lower in bladder cancer tissue than in normal bladder tissue. In addition, bladder cancer cell lines showed reduced EPAC1 mRNA expression. Furthermore, EPAC1 overexpression in bladder cancer cell lines induced morphologic changes and markedly suppressed cell migration without affecting cell viability. The overexpressed EPAC1 preferentially localized at cell-cell interfaces. In conclusion, reduced EPAC1 expression in bladder tumors and poor migration of EPAC1-overexpressing cells implicate EPAC1 as an inhibitor of bladder cancer cell migration.
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| Free Research Field |
泌尿器科学
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