2016 Fiscal Year Final Research Report
Control of Human NKT cell Responses by Immunoregulatory Liposomes and Anti- CD40 Antibody
| Project/Area Number |
15K20115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MIYAIRI SATOSHI 東京女子医科大学, 医学部, 医療練士研修生 (20623391)
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| Research Collaborator |
ISHII Yasuyuki
FUKUDA Emi
ABE Ryo
HIRAI Toshihito
TANABE Kazunari
IKEMIYAGI Masako
ISHII Rumi
KATSUMATA Haruki
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 移植免疫寛容 / α-galactosylceramide / 抗CD40抗体 / 調節性T細胞 / ナチュラルキラーT細胞 |
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| Outline of Final Research Achievements |
We previously reported that combination treatment of a novel natural killer cell stimulator, liposomal α-galactosylceramide (lipo-αGC), and anti-CD40L monoclonal antibody induced stable mixed hematopoietic chimerism and subsequent allograft tolerance in a murine cardiac transplant model. The current study demonstrated that Lipo-αGC promoted regulatory T cell expansion and augmented interferon-gamma production in a human peripheral mononuclear cell culture system. However, no significant combined effects of lipo-αGC and antibody for CD40-CD40 ligand blockade were observed in the in vitro system. In future, we should further investigate the effects of both agents in a human in vitro system that takes into account immunological factors, responses and reactions in transplantation.
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| Free Research Field |
移植免疫
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