2016 Fiscal Year Final Research Report
Progesterone is a new therapeutic agent for neonatal hypoxic ischemic encephalopathy.
Project/Area Number |
15K20127
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 低酸素性脳虚血性脳症 / 脳神経保護 / 新生児 / 周産期 / プロゲステロン / GABA受容体 |
Outline of Final Research Achievements |
Neonatal hypoxic ischemic encephalopathy (HIE) is a general term of brain damages that lead to behavioral and learning disorders. Recently, some studies revealed progesterone (P4) has neuroprotective effects due to the action of allopregnanolone (Allo), which is a metabolite of P4, to GABA receptors. In this study the therapeutic effect for the brain damage of P4 was investigated using a rat HIE model, which was suffered by transient uterine artery ligation. After birth, P4, medroxyprogesterone acetate (MPA), or Allo were administered to each group. Brain damages were evaluated by the histological analyses and the motor coordinate test (the rotarod test). The impaired latency of the rotarod test in HIE models were restored by P4 and Allo, but not MPA. Histologically, brain lesions were recognized as decreased neurons and so on. P4 and Allo also restored these histological lesions. Collectively, our study indicates that P4 can restore the brain damages of HIE via GABAA receptors.
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Free Research Field |
周産期
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