2016 Fiscal Year Final Research Report
Dendritic cell involvment in endometriosis
| Project/Area Number |
15K20129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IZUMI Gentaro 東京大学, 医学部附属病院, 助教 (30714125)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 子宮内膜症 / 樹状細胞 / 子宮卵管造影 / 逆流説 / 腹腔 |
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| Outline of Final Research Achievements |
We analyse Myeloid dendritic cell type I(MDC1) in the peritoneal cavity. In endmetriosis patient, CD206 expression is significantly higher in endometriosis patients, though other type C lectin such as CLEC1, CLEC2, Dectin-1, Dectin-2 is not different.
Next, we blocked the expression of CD206 by D-mannan on dendritic cell. Endometriotic cell phagocytosis by dendritic cell was supressed by d-mannan. From our experiment, CD206 on dendritic cell in peritoneal cavity of endometriosis patients progress phagocytosis of endometriotic cells in retrograde menstruation, thus progress the endometriosis by secration of inflamattory cytokines.
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| Free Research Field |
生殖医療
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