2016 Fiscal Year Final Research Report
Elucidation of cancer immunity escape mechanism in gynecological cancer
| Project/Area Number |
15K20149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 婦人科腫瘍 / がん免疫 |
|---|
| Outline of Final Research Achievements |
Because of the deficiency of the tumor suppressor Menin, T cell antitumor activity decreased, which is thought to be caused by exhaustion in T cells. Therefore, we succeeded in constructing a model of tumor-bearing mice in which the antitumor activity of T cells was decreased due to Menin deficiency. From now on, we intend to develop a method for enhancing antitumor activity by suppressing fatigue mainly in this T cell exhaustion mouse model.
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| Free Research Field |
婦人科腫瘍学
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