Immunohistochemical analysis of macrophages in the placental chorionic villi for the elucidation of the pathogenesis of fetal inflammatory response syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20150
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kumamoto University
• Principal Investigator: Munekage Yamaguchi 熊本大学, 大学院生命科学研究部(医), 助教 (20626535)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 早産 / 胎児炎症反応症候群 / マクロファージ / 絨毛膜羊膜炎 / 抗炎症性マクロファージ / 脳室周囲白質軟化症 / 慢性肺疾患

Outline of Final Research Achievements

Maternal hypercytokinemia associated with preterm labor induces fetal inflammatory response syndrome (FIRS) and increases the risk of neonatal complications. The association between preterm labor and decidual macrophages of maternal origin has been reported. However, the association between preterm labor and placental chorionic macrophages of fetal origin remains unknown. This study examined the involvement of phenotype of chorionic macrophages in the neonatal outcome associated with FIRS. The immunohistochemical analysis revealed that the number of anti-inflammatory macrophages in the placental chorionic villi was significantly decreased in preterm newborn diagnosed with periventricular leukomalacia (PVL) or chronic lung disease (CLD). The increased number of inflammatory macrophages in the chorionic villi may be associated with the pathogenesis of PVL or CLD.

Free Research Field

産科婦人科