The mechanism of chemokine system in endometriosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20155
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Wakayama Medical University
• Principal Investigator: Mizoguchi Mika 和歌山県立医科大学, 医学部, 助教 (80647561)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 子宮内膜症 / ケモカイン

Outline of Final Research Achievements

We established mouse endometriosis model. The endometriotic cysts were formed 10/16 (62.5%)in Balb / c and 6/16(37.5%) in c57 BL / 6. This cyst epithelium expressed estrogen receptor and progesterone receptor. Thus, these cysts were confirmed endomtriotic cyst. In CCR5 deficient (KO) mice, the lesions were not formed in combination donor KO and recipient KO. The rate of lesion formation was 4/10 (40%), in WT - KO and 4/9(44.4%) in KO - WT. The endometiotic cysts were suppressed significantly in KO - KO. These results suggest that the CCL5-CCR5 system of endometrium itself and intraperitoneal environment plays essential role in endometriosis.

Free Research Field

産婦人科学