Artery embolization using n-butyl cyanoacrylate in cynomolgus monkeys

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20165
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: Igarashi Suguru 聖マリアンナ医科大学, 医学部, 講師 (00386955)
• Research Collaborator: Arai Yasunori 聖マリアンナ医科大学, 医学部, 助教 ; Kazuki Hashimoto 聖マリアンナ医科大学, 医学部, 助教
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 産科危機的出血 / NBCA

Outline of Final Research Achievements

The safety of transcatheter arterial embolization using NBCA (n-butyl cyanoacrylate), a liquid embolic substance, to be performed on obstetric crisis bleeding was examined. Uterine artery was embolused from the internal iliac arteries on both sides using NBCA for female 4 years old and 2 females, and change in uterine blood flow was observed by contrast CT examination over time. We also evaluated the uterus and blood vessels removed.
Both of them showed contrast effect in the arterial phase at 1 month after embolization. In the histological examination of the internal iliac artery, uterine artery and uterus, which had been removed one month after embolization, an image of recanalization was observed with NBCA remaining in the uterine artery. Furthermore, there was no obvious necrotic image in the uterus. Uterine arterial embolization by NBCA suggested that blood flow was secured and it was safe even after embolization.

Free Research Field

産科危機的出血