2016 Fiscal Year Final Research Report
Combinatorial Immunotherapy of poly-IC and anti-PD-L1 antibody for head and neck malignancies
| Project/Area Number |
15K20172
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | poly-IC / PD-L1 / PD-1 / 頭頸部悪性腫瘍 / 扁平上皮癌 / 鼻性NK/T細胞リンパ腫 |
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| Outline of Final Research Achievements |
We detected the expression of PD-L1 in biopsy samples from nasal NK/T-cell lymphoma (NNKTL) patients. PD-L1 was found on both malignant cells and tumor-infiltrating macrophages, while PD-1-positive mononuclear cells also infiltrated the tumor tissues. Most significantly, soluble PD-L1 (sPD-L1) was present in sera of NNKTL patients at higher levels as compared to healthy individuals. In addition, the high sPD-L1 group of patients showed significantly worse prognosis than the low sPD-L1 group. Furthermore, we confirmed that membrane and soluble PD-L1 was expressed on the surface and in the culture supernatant, respectively, of NNKTL cell lines. The expression of PD-L1 was observed in tumor tissues and sera from a murine xenograft model inoculated with an NNKTL cell line. Our results suggest that sPD-L1 could be a prognostic predictor for NNKTL and open up the possibility of immunotherapy of this lymphoma using PD-1/PD-L1 axis inhibitors.
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| Free Research Field |
耳鼻咽喉科・頭頸部外科学
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