Circulating Epstein-Barr virus-encoded microRNAs as potential biomarkers for nasal natural killer/T-cell lymphoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20173
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital (2016); Asahikawa Medical College (2015)
• Principal Investigator: Komabayashi Yuki 医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, がん研究部, 研究員 (40548864)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: EBウイルス / microRNA / 悪性リンパ腫 / miR-BART2-5p

Outline of Final Research Achievements

Nasal natural killer /T-cell lymphoma is an Epstein-Barr virus (EBV)-associated malignancy and is characterized by a poor prognosis. Sera of patients with nasal natural killer /T-cell lymphoma were subjected to PCR-based EBV-miRNA profiling. This analysis revealed high miR-BART2-5p expression level in sera of patients. Level of miR-BART2-5p significantly decreased after treatment compared with those before treatment. Furthermore, a high circulating miR-BART2-5p level was associated with disease progression and poor prognosis in patients with nasal natural killer /T-cell lymphoma. Our findings suggest that circulating miR-BART2-5p may serve as a potential biomarker in patients with nasal natural killer /T-cell lymphoma.

Free Research Field

頭頸部外科学