2017 Fiscal Year Final Research Report
CD98 is the marker of cancer stem cell and radioresistance
| Project/Area Number |
15K20177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | CD98hc / 癌幹細胞 / 放射線耐性 / 頭頸部扁平上皮癌 |
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| Outline of Final Research Achievements |
In head and neck cancer, failure in radiotherapy causes subsequent life prognosis failure. 60 Gy radiation was applied to five head and neck squamous cell carcinoma cell lines HO-1-u-1, Sa 3, HSC 2, HSC 3, HSC 4. Overexpression of CD98hc was confirmed in all cells, and Colony forming ability and migration ability were enhanced. When only CD98hc positive cells were extracted, it was found that Colony forming ability, invasion ability, and adhesion ability were enhanced as compared with the negative cells. Furthermore, it had high tumorigenicity in animal experiments. The amino acid transporter CD98hc will be a target for cancer therapy.
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| Free Research Field |
癌幹細胞
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