Determination of the invasion mechanism of adenoid cystic carcinoma using patient-derived xenograft model

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20186
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: Ando Mizuo 東京大学, 医学部附属病院, 講師 (60511467)
• Research Collaborator: KAWAZU Masahito ; MATSUMOTO Yu
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腺様嚢胞癌 / 動物モデル / 遠隔転移

Outline of Final Research Achievements

We generated three PDX (patient-derived xenograft) models from patients with adenoid cystic carcinoma. One model has distant pulmonary metastasis which is of substantial importance on deciphering the mechanisms of invasion in adenoid cystic carcinoma. By comparing genome-wide data of patient’s peripheral blood, primary tumor, and PDXs (subcutaneous tumor and lung metastasis), we detected characteristic genomic alterations of metastatic tumor cells. To reveal factors promoting metastasis, we examined intravenous administration and invasive surgical procedure to the PDX model but failed to identify any possible factors that might affect metastatic potential. We have also developed the international research project collaborated with University of California, San Diego.

Free Research Field

頭頸部悪性腫瘍