Local increase in IgE in nasal polyps in chronic rhinosinusitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20187
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: Baba Shintaro 東京大学, 医学部附属病院, 届出診療員 (90553719)
• Co-Investigator(Renkei-kenkyūsha): OOTA Ken 国立病院機構, 東京病院, 院長 (30160500)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 副鼻腔炎 / 好酸球 / IgE / マスト細胞

Outline of Final Research Achievements

To investigate the distribution, phenotypes, and immunoglobulin E (IgE) positivity of mast cells in these 2 subtypes of Chronic rhinosinusitis with nasal polyps (CRSwNP).
Expression of tryptase mRNA was significantly increased in nasal polyps from patients with the　2 subtypes of CRSwNP compared with controls. Immunohistochemistry showed increased numbers of　tryptase-positive mast cells in the epithelium, glands, and submucosa of ECRS polyps, whereas the number
of tryptase- and chymase-positive mast cells was increased in the glands and submucosa of non-ECRS　polyps. IgE-positive mast cells were abundant in the epithelial, glandular, and submucosal regions of　ECRS polyps but few were detected in non-ECRS polyps.　The present study demonstrates that the distribution, subtype population, and IgE positivity of　mast cells is different between ECRS and non-ECRS nasal polyps. Our results suggest a role for IgE-mediated　mast cell activation in the pathogenesis of ECRS.

Free Research Field

鼻科学