2017 Fiscal Year Final Research Report
Molecular biological research into anti-aging of voice using calorie restriction
| Project/Area Number |
15K20188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Yamauchi Akihito 国立研究開発法人国立国際医療研究センター, その他部局等, 耳鼻咽喉科医師 (90612507)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 音声 / 老化 / アンチエイジング / カロリー制限 / 粘膜固有層 / 声帯瘢痕 / 長寿遺伝子 |
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| Outline of Final Research Achievements |
The present study aimed at the invastigation of effects of short-term calorie restriction on the vocal fold lamina propria of young male rats as a basic research for anti-aging approaches toward age-related voice problems (presbyphonia).
Histological and immunohistological study revealed that rats with calorie restriction showed increased hyaluronic acid and sirt1, decreased collagen type III and oxydative stress, and ameliorated vocal fold scarring in response to the vocal fold injury. RT-PCR showed that calorie restricted rats demonstrated suppressed breakdown of hyaluronic acid, suppressed collagen production, and elevated sirt1.
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| Free Research Field |
音声
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