2017 Fiscal Year Final Research Report
Association between activation induced cytidine deaminase and HPV positive oropharyngeal carcinogenesis
| Project/Area Number |
15K20192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIZAKI Tomokazu 金沢大学, 医学系, 教授 (70262582)
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| Research Collaborator |
WAKISAKA Naohiro 金沢大学, 医学系, 准教授 (70377414)
KONDO Satoru 金沢大学, 附属病院, 講師 (70436822)
ENDO Kazuhira 金沢大学, 附属病院, 助教 (30547154)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 中咽頭癌 / 喉頭乳頭腫 / APOBEC family |
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| Outline of Final Research Achievements |
We found that the expression of the apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) 3A, C, F, and H was higher in HPV positive oropharyngeal cancer (OPC) tissues than HPV negative OPC tissues. However, only the A3F was expressed in HPV positive laryngeal papilloma. We failed in conducting the transduction of the HPV gene into oropharyngeal cancer cell line because of low transduction efficiency.
We identified APOBEC family highly expressed in oropharyngeal cancer, It was suggested that laryngeal papilloma avoided the host immune response.
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| Free Research Field |
頭頸部癌
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