• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

The pathology of eosinophilic chronic rhinosinusitis focused on eosinophil-fibroblast interactions.

Research Project

  • PDF
Project/Area Number 15K20200
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionShiga University of Medical Science

Principal Investigator

Takezawa-Yasuoka Kumiko  滋賀医科大学, 医学部, 非常勤講師 (80711837)

Research Collaborator Shimizu Shino  
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords好酸球性副鼻腔炎 / 線維芽細胞 / 好酸球 / 凝固因子 / EGF受容体阻害薬
Outline of Final Research Achievements

Eosinophilic chronic rhinosinusitis (ECRS) is a refractory upper airway disease, characterized by significant eosinophil infiltration, glue-like rhinorrhea and recurrent nasal polyposis.
In the present study, we found that eosinophil-fibroblast interactions promoted infiltration of inflammatory cell such as neutrophil and eosinophil. We also elucidated that tissue factor expression by eosinophil activated coagulation cascade, and coagulation factors stimulated nasal mucosa fibroblasts via protease-activated receptors (PARs). As a result, deposition of extracellular matrix and eosinophil infiltration induced. Intranasal instillation of EGFR tyrosine kinase suppressed eosinophil infiltration and goblet cell metaplasia in ovalbumin (OVA)-induced allergic inflammation of rat nose. The results indicate that local administration of EGFR inhibitor may provide a new therapeutic potential for the treatment of intractable airway diseases such as ECRS.

Free Research Field

耳鼻咽喉科学

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi