2017 Fiscal Year Final Research Report
Sema4A on nasal polyp eosinophils
| Project/Area Number |
15K20206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka University |
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Principal Investigator |
Maeda Yohei 大阪大学, 医学系研究科, 助教 (00636483)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 好酸球性副鼻腔炎 / 好酸球 / セマフォリン |
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| Outline of Final Research Achievements |
Serum SEMA4A levels were markedly elevated in patients with eosinophilic chronic rhinosinusitis (ECRS) and asthma patients. Moreover, SEMA4A was strongly expressed in eosinophils in both nasal polyps and eosinophils in peripheral blood. Consistent with these results, bone marrow derived eosinophils from SEMA4A-deficient mice showed shorter survival and less activation than those from wild type mice.
Conclusion: These results suggest that SEMA4A potentially exacerbate Th2 inflammation through promoting eosinophil survival and activation and can be a marker for discriminating specific endotype in ECRS and asthma.
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| Free Research Field |
耳鼻咽喉科学
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