2017 Fiscal Year Final Research Report
Mechanism and potential new treatment for salivary gland carcinomas.
| Project/Area Number |
15K20208
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 粘表皮癌 / CRTC1-MAML2 / AREG / EGFR |
|---|
| Outline of Final Research Achievements |
In mucoepidermoid carcinoma (MEC), CRTC1-MAML2 fusion indicates a favorable prognosis. Amphiregulin (AREG), an EGFR ligand, has been shown to be a downstream target of CRTC1-MAML2 fusion, and to play a role in tumor growth and survival in CRTC1-MAML2-positive MEC cell lines. The aim of this study was to characterize the AREG and EGFR expression in the fusion positive and -negative MEC of the major salivary gland. AREG and EGFR expression was studied by immunochemistry in 33 MEC cases of the major salivary glands. CRTC1-MAML2 fusion was tested by RT-PCR (23 CRTC1-MAML2 fusion-positive, 10 fusion-negative). There was a positive correlation between CRTC1-MAML2 fusion and AREG overexpression (P < 0.01). AREG overexpression was associated with a longer disease free survival of the MEC patients (P = 0.042). Detection of AREG expression may be useful for identifying CRTC1-MAML2-positive MECs and as a marker for favorable prognosis.
|
| Free Research Field |
唾液腺
|
