2016 Fiscal Year Final Research Report
Expression of innate lympgoid cell and its response to microbial components in eosinophilic upper airway inflammation
| Project/Area Number |
15K20210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 自然リンパ球 / 好酸球性副鼻腔炎 / IL-5 / IL-13 / 鼻茸 |
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| Outline of Final Research Achievements |
Eosinophilic chronic sinusitis shows increased innate lymphoid cells in the tissue. Although, little is known about the role of innate lymphoid cells. In this research, we examined the expression and the role of innate lymphoid cells in eosinophilic sinusitis. We use nasal polyp cell which were collected at the sinus surely. Innate lympgoid cells are known for the strong cytokine producing ability. Innate lympgoid cells were isolated from nasal polyp cells and stimulated with staphylococcal enterotoxin B.
Innate lympgoid cells showed enhanced production of type 2 cytokines which exacerbate eosinophilic inflammation. On the other hand, production of type 1 cytokines seem to be inhibited.
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| Free Research Field |
鼻科学、アレルギー・免疫学
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