2017 Fiscal Year Final Research Report
Development of novel treatment to radiological salivary gland dysfunction
| Project/Area Number |
15K20212
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 放射線性唾液腺障害 / rapamycin |
|---|
| Outline of Final Research Achievements |
Radiation therapy is effective for head and neck squamous cell carcinoma and useful for organ preservation, however radiation induces permanent xerostomia due to salivary gland damage. It is reported that ramapycin, mTOR inhibitor, removes intracellular reactive oxygen species(ROS) in human oral keratinocytes and prevents senescence. This study shows rapamycin inhibits intracellular ROS production in normal salivary gland cell. This result indicates rapamycin inhibits ROS in irradiated salivary gland cells, too. Moreover, rapamycin might protect radiation induced salivary gland disorder.
|
| Free Research Field |
耳鼻咽喉・頭頸部外科
|
