2016 Fiscal Year Final Research Report
Fabrication of the artificial trachea which induces sustained growth factor signaling
| Project/Area Number |
15K20215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University (2016)
Fukushima Medical University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 気管 / ヘパリン / FGF-2 / 再生 / 線毛 |
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| Outline of Final Research Achievements |
Our group developed an artificial trachea capable of inducing in situ tissue regeneration, and
have clinically used the artificial trachea for reconstructing tracheal defects, which were generated by resecting regions suffering from stenosis or malignant tumors. Because FGF-2 reportedly promotes epithelial regeneration, we investigated a method for supplying FGF-2 to the reconstruction area effectively. Heparin-conjugation to collagen sponge, which is main component of the artificial trachea, delayed loss of FGF-2 from the collagen sponge. Implantation study suggested the heparin-conjugated collagen sponge retaining FGF-2 prolonged effects of FGF-2 on cells invading to the sponge, and promoted epithelial regeneration.
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| Free Research Field |
医歯薬学
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