2017 Fiscal Year Final Research Report
Analysis of COX-2 expression and elucidation of anticancer drug resistance mechanism in head and neck cancers
| Project/Area Number |
15K20225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IMANISHI Yorihisa 慶應義塾大学, 医学部, 講師 (80255538)
OZAWA Hiroyuki 慶應義塾大学, 医学部, 専任講師 (30327621)
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| Research Collaborator |
SEKIMIZU Mariko
IKARI Yuichiro
SAITO Shin
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 咽頭癌 / 頭頸部癌 / TOVS / ELPS / COX2 |
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| Outline of Final Research Achievements |
Expression of CDH1 was increased by the COX 2 inhibitor and the EP 2 inhibitor on the pharyngeal cancer cell line. Immunofluorescent staining also enhanced membrane expression of E-cadherin. The migration assay showed pharyngeal cancer cell inhibitory effect. These agents are expected to have metastasis inhibitory effects on cancer. Immunohistochemical staining of COX 2 and E-cadherin in oral excised tissues of laryngeal carcinoma was also performed. Multivariate analysis was carried out based on the results and clinical data, and it was shown that COX2 expression march and E-cadherin expression decrease are independent regulators of cervical lymph node metastasis. It was suggested that cervical lymph node metastasis of pharyngeal epithelial carcinoma is deeply involved in COX2 expression upregulation and E-cadherin expression decrease.
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| Free Research Field |
頭頸部癌
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