The Receptor-Associated Prorenin System Is Associated with the Molecular Pathogenesis of Human Conjunctival Lymphoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20241
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: Ando Ryo 北海道大学, 大学病院, 医員 (60399847)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 眼細胞生物学 / レニン・アンジオテンシン系 / 結膜リンパ腫 / （プロ）レニン受容体

Outline of Final Research Achievements

Extranodal marginal zone B-cell lymphoma (EMZL) is the most common subtype of conjunctival lymphoma though its molecular mechanisms of pathogenesis are largely unknown. Here, we attempted to explore the association of the renin-angiotensin system (RAS) and (pro)renin receptor [(P)RR] in the pathogenesis of conjunctival lymphoma. Surgically removed conjunctiva EMZL samples were used for gene expression, immunohistochemical and immunofluorescence analyses of (P)RR and RAS components. The present study suggests that activation of (P)RR and AT1R is associated with the pathogenesis of conjunctival EMZL by stimulating the production of FGF2 and MMPs.

Free Research Field

眼科学