New treatment for intraocular proliferative diseases using trehalose

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20246
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Hirosaki University
• Principal Investigator: Adachi Kbu 弘前大学, 医学部附属病院, 助教 (60620862)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: トレハロース / 眼内増殖性疾患 / 増殖糖尿病網膜症

Outline of Final Research Achievements

Recently, our lab clarified that trehalose has an inhibitory effect on proliferation of fibroblasts and vascular endothelial cells whereas it has a protective effect on surface epithelial cells. In this study, we tried to investigate whether or not trehalose has an inhibitory effect on growth of fibroblasts by vitreous fluid obtained from various intraocular diseases, including proliferative diabetic retinopathy. I employed cultured ARPE-19 cell in the collagen gel with or without trehalose. There was no statistical deference between gels containing trehalose and gels without trehalose in terms of shrinkage of ARPR-19 collagen gels with vitreous fluid.

Free Research Field

眼科学