Development of neuroprotective treatments for ischemic eye diseases.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20255
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: Hata Masayuki 京都大学, 臨床研究総合センター, 助教 (70748269)
• Research Collaborator: IKEDA Hanako 京都大学, 医学部附属病院臨床研究総合センター, 准教授 ; MURAOKA Yuki 京都大学, 大学院医学研究科眼科学, 助教 ; HASEGAWA Tomoko 京都大学, 大学院医学研究科眼科学, 大学院生 ; KAKIZUKA Akira 京都大学, 生命科学研究科 高次生体統御学, 教授
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 虚血性眼疾患 / 神経保護薬 / VCPタンパク / ATPase

Outline of Final Research Achievements

In this study, we investigated the neuroprotective effects of VCP ATPase inhibitor for ischemic eye diseases. We showed that the VCP modulator exerts a profound anti-apoptotic effect on ischemic retinal injury by suppressing ER stress, resulting in morphological and functional neuroprotection. Our findings may provide a novel therapeutic strategy for the treatment of neural ischemic diseases.

Free Research Field

難治性網膜視神経疾患の病態解明および治療法開発